目的

探讨青年和老年女性乳腺癌患者的临床特征与预后的关系。

方法

回顾性研究2005 年1 月至2007 年1 月新疆肿瘤医院和新疆奎屯农七师医院收治的83 例青年女性乳腺癌患者(≤35 岁)及92 例老年女性乳腺癌(≥65 岁) 的临床和病理资料,比较无瘤生存率(DFS)的差异。 两组临床数据(淋巴结转移、浸润性导管癌、ER、PR、C-erbB-2、P53、手术方式、是否放、化疗、内分泌治疗)比较采用χ² 检验;肿瘤直径、肿瘤分期采用秩和检验;生存分析采用Kaplan-Meier 法,以P<0.05 为差异有统计学意义。

结果

两组患者在肿块大小、腋窝淋巴结转移情况、ER、C-erbB-2 的差异均有统计学意义(P<0.05);两组患者的病理类型、PR、P53 比较差异无统计学意义(P>0.05);两组患者治疗方式无明显差别,青年组5 年的DFS 低于老年,且差异具有统计学意义(P<0.05)。

结论

青年乳腺癌恶性程度高并且预后差,而老年乳腺癌恶性程度较低,预后较好。

Objective

To compare the clinico-pathological data and prognosis between young and old patients with breast cancer.

Methods

We retrospectively analyzed the clinico-pathological data of 83 young breast cancer patients (≤35 years) and 92 elderly breast cancer patients (≤65 years) in Xinjiang Cancer Hospital and the Seventh Agriculture Division Hospital of Kuitun from January 2005 to January 2007 in order to compare the disease-free survival (DFS). The clinical data in the two groups (including lymph node metastasis, invasive ductal carcinoma, ER and PR, C-erbB-2, p53, surgical approach,radiotherapy, chemotherapy, and endocrine therapy) were compared using the χ² test. The tumor size and tumor stage were compared using the rank sum test. Survival analysis was performed using Kaplan-Meier method. P<0.05 was considered as statistical difference.

Results

There were significant differences on tumor size, lymph node metastasis, ER,PR and C-erbB-2 expression between the young patients and the elderly patients(P<0.05),while no statistical difference was present on pathological type, PR and P53(P>0.05). The two groups showed no significant difference in surgical approach. The 5-year DFS in the young patients was significantly lower than that of the elderly patients (P < 0.05).

Conclusion

Compared with young patients, the elderly breast cancer patients showed less malignancy and better prognosis.